Gene Polymorphism of XRCC1 in Systemic Lupus Erythematous

Introduction: There are debates about the role of X-ray repair cross-complementation group 1 (XRCC1) Arg399Gln gene in pathogenesis Systemic Lupus Erythematosus (SLE). Methods: The study was a case-control carried out on 100 recently diagnosed SLE patients compared to control subjects. XRCC1 polymorphism performed by polymerase chain reaction and restriction fragment length polymorphism. Results Discussion: A higher frequency ‘G’ allele (38.5%) versus (32%) noticed; however, this difference not statistically significant (p = 0.174). Besides, slightly G/G genotype found (22%) vs . (12%); again, 0.157). significantly proportion arthritis, serositis, thrombocytopenia observed A/A 0.010, 0.032, 0.036, respectively). Furthermore, we noticed lower hemoglobin level 0.027). Otherwise, there no between three genotypes regarding other parameters: photosensitivity, malar rash, oral ulceration, ANA, anti-dsDNA antibody, anemia, leucopenia, neurologic manifestations, all lab parameters except level. Similar results were reported previously. According genotype, Clinical laboratory patients, =0 .01, 0.036 These findings suggest pathogenic connection seriousness defective DNA autoimmune severity; such is consistent with that several murine models. Additionally, negative regulation genes encoding proteins involved NER pathway specifically XPC, has been Conclusion: present highlights insignificant increase G GG 399 healthy control. This associated anemia which may reflect aggravation environmental risk factors reduced DNA. Further longitudinal studies required validate findings.